I have a 22 4.0. The new one is a nice piece of kit. Are you planning on racing it? If so the spektrum motor esc combo isn't going to do you much good. Check your local tracks rule set for what motor limits they have and pair it with an esc that can handle the amperage. I've had good experience...
Nvidia still seems to have the upper hand on the GPU market at the moment. I have used both, but if I were to purchase a new card today id be looking at the RTX 30 series.
Honestly I've only ever used AMD processors in my desktop builds. Initially because of the price point difference, but more recently the overall performance vs value has increased significantly. Nothing against Intel processors there just expensive, but my preferred processor for laptops...